MR2-HM00V-100μg / 詢價
MR2-HM00V-100μgx5 / 詢價
MR2-HM00V-100μgx10 / 詢價
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Human MRGPRX2 VLP
Recombinant Human MRGPRX2 VLP is expressed from HEK293.It contains Met1-Val330 (It may have cross reaction with anti-His antibody) [Accession | Q96LB1].
The target protein has a predicted MW of 40.31 kDa.
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology.
MRGX2
Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis? Exp Dermatol. 2020 Nov;29(11):1104-1111. doi: 10.1111/exd.14182. Epub 2020 Sep 17. PMID: 32866307.
