JAG-HM101-100μg / 詢價
JAG-HM101-500μg / 詢價
JAG-HM101-500μgx2 / 詢價
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Human Jagged 1/JAG1 Protein
Recombinant Human Jagged 1/JAG1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln34-Ser1046 [Accession | P78504-1].
The protein has a predicted MW of 111.56 kDa. Due to glycosylation, the protein migrates to 130-160 kDa based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Less than 1 EU per μg by the LAL method.
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
-20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3 months after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
JAGGED1 (JAG1) is composed of a relatively small intracellular domain, a transmembrane domain and a larger extracellular component. JAG1 is widely expressed throughout mammalian development, across many tissues and developmental stages. The Notch signaling pathway and JAG1 in particular have been implicated in multiple forms of cancer and multiple aspects of cancer biology including tumor angiogenesis, neoplastic cell growth, cancer stem cell maintenance and the metastatic process.
Jagged1; hJ1; CD339; JAGL1; AGS; AHD; AWS
Grochowski CM, Loomes KM, Spinner NB. Jagged1 (JAG1): Structure, expression, and disease associations. Gene. 2016 Jan 15;576(1 Pt 3):381-4. doi: 10.1016/j.gene.2015.10.065. Epub 2015 Nov 6. PMID: 26548814; PMCID: PMC4673022.
